Venture Investments in Israel - A Regional Perspective Dafna Schwartz and Raphael Bar-El Ben-Gurion University, School of Management, Israel

Venture Investments in Israel – a Regional Perspective This paper analyzes the geographic distribution of venture investments in start-ups in Israel, using data for the period of 1995-2004. The findings show that their location behavior differs from that of high-tech activities: they show a pattern of "dispersed concentration" (as compared with a pattern of "concentrated concentration" of high-tech activity), with high levels of concentration in focal places, but at a commuting distance from the main metropolis. This is explained by the fact that venture investors also play the role of entrepreneurs and managers. The comparison between different types of venture investors shows that local venture capital funds lead to the heaviest concentration in the metropolis, in comparison with foreign venture investors. This heavy concentration of venture investments implies increasing regional gaps, with a minimal participation of peripheral regions, even those that enjoy some high-tech activity.

Spatial urban restructuring for economic growth with distribution: The case of Ceara (Brazil)

One of the most important challenges of economic policy is the combination between economic growth and the reduction of inequality and poverty. The change of the regime in Brazil can be seen as a reaction to the failure of economic policy in this field. We focus on the case of one of Brazil's states in the Northeast, Ceara, that experienced a rapid macro economic growth in the last decade, but with no reduction of poverty and inequality. Established economic theory shows that economic growth generally implies a changing economic structure (relatively less agriculture, and more industry and later services), and a process of urbanization. Our hypothesis is that in addition to industrialization and urbanization, a component of spatial urban restructuring is necessary for the achievement of a more equalitarian economic growth. The persistence of inequalities and high levels of poverty in spite of the macro economic growth can be explained by the continuing high level of urban concentration, and the insufficient growth of urban centers outside the metropolis. We test this using data of economic growth in Ceara, compared with trends of urbanization and its concentration level, changing economic structures (distribution between agriculture, industry and services) in the regions outside the metropolis and levels of productivity. Results lead to the conclusion that economic policy measures should consider a spatial reallocation of public expenditures for physical and human infrastructures, leading to a spatial urban restructuring.

Targeted consultancy services as an instrument for the development of rural SMEs - a brazilian case

One of the problems that policy makers face in the process of development in many countries is the inequality between the periphery and the metropolis center. The periphery has difficulties making the structural adjustments needed to fit in the national growth, leading to growing unemployment rates, regional gaps and continuous migration to the big metropolis. One of the sectors that has a difficulty making the transition is the small business sector. Amongst the reasons is in-adequate skills and information of the business management and in some cases a lack of awareness to the importance of these fields in the potential growth to the business. In addition the government support systems for small businesses do not give an adequate response. Support programs for small businesses are mostly provided within the urban sector, and are not adapted to the needs of the rural sector. The outcome is that although there is a "potential" need among small businesses in the interior for business consultant's services and in-spite of there being a wide range system of support for small businesses at the national level, their access to such services is limited. As a consequence of the potential demand that doesn't come into expression in the existing structure and of a national supply of these services that does not meet the needs of this sector, the gaps between the rural area and the urban central area grows. Our hypothesis is that an effort to establish a link between the unexpressed demand and the inappropriate supply of services to small-scale businesses in the rural area may contribute to economic growth. We test this hypothesis by using a program that was launched in the state of Ceara, Brazil, that is set to aim at both the demand and supply, focusing on a specific population: non-agricultural businesses in the rural region. The program is intended in the first stage to create awareness in the business community to the potential for business development and to encourage their demand for such services. The program offers consultancy services suited to the special needs of businesses in the non-metropolitan region adopting a reach-out approach. The program is part of the San Jose Project directed by the Secretary of Rural Development of the State of Ceara, that is aimed to bring a reduction in poverty in rural poor areas. The first stage of the research is to identify the potential of demand for consulting services and identifying the main areas in which the consulting is needed. A questionnaire was applied to 224 entrepreneurs in three selected areas. The findings show that about all the entrepreneurs are interested in receiving the consulting services. 90% of them evaluated that they had a growth potential. The factors that they point out as main constraints are, in order: physical infrastructures (65%), marketing (60%), capital returns (52%) problems in management and labor force (37%) and administration problems (35%). The second stage of the research was focused on 140 entrepreneurs who responded to a few basic criteria and were entitled to receive basic consulting services, of up to 15 hours. At this stage the marketing turned up as a main problem, especially for businesses that are in a process of transition from local to national markets. The findings show also that the support system that provides the consultancy services needs to go through a process of adaptation. One important difficulty of the system is to switch from internal advisers to external ones who specialize in the field.

Experimental demonstration of a dual-frequency laser free from anti-phase noise

A reduction of more than 20 dB of the intensity noise at the anti-phase relaxation oscillation frequency is experimentally demonstrated in a two-polarization dual-frequency solid-state laser without any optical or electronic feedback loop. Such a behavior is inherently obtained by aligning the two orthogonally polarized oscillating modes with the crystallographic axes of a (100)-cut neodymium-doped yttrium aluminum garnet active medium. The anti-phase noise level is shown to increase as soon as one departs from this peculiar configuration, evidencing the predominant role of the nonlinear coupling constant. This experimental demonstration opens new perspectives on the design and realization of extremely low noise dual-frequency solid-state lasers

Sensing and control of segmented mirrors with a pyramid wavefront sensor in the presence of spiders

The segmentation of the telescope pupil (by spiders & the segmented M4) create areas of phase isolated by the width of the spiders on the wavefront sensor (WFS), breaking the spatial continuity of the wavefront. The poor sensitivity of the Pyramid WFS (PWFS) to differential piston leads to badly seen and therefore uncontrollable differential pistons. In close loop operation, differential pistons between segments will settle around integer values of the average sensing wavelength. The differential pistons typically range from one to ten times the sensing wavelength and vary rapidly over time, leading to extremely poor performance. In addition, aberrations created by atmospheric turbulence will contain large amounts of differential piston between the segments. Removing piston contribution over each of the DM segments leads to poor performance. In an attempt to reduce the impact of unwanted differential pistons that are injected by the AO correction, we compare three different approaches. We first limit ourselves to only use the information measured by the PWFS, in particular by reducing the modulation. We show that using this information sensibly is important but will not be sufficient. We discuss possible ways of improvement by using prior information. A second approach is based on phase closure of the DM commands and assumes the continuity of the correction wavefront over the entire unsegmented pupil. The last approach is based on the pair-wise slaving of edge actuators and shows the best results. We compare the performance of these methods using realistic end-to-end simulations. We find that pair-wise slaving leads to a small increase of the total wavefront error, only adding between 20-45 nm RMS in quadrature for seeing conditions between 0.45-0.85 arcsec. Finally, we discuss the possibility of combining the different proposed solutions to increase robustness.Comment: 12 pages, 15 figures, AO4ELT5 Proceedings, Adaptive Optics for Extremely Large Telescopes 5, Conference Proceeding, Tenerife, Canary Islands, Spain, June 25-30, 201

3-(Benzothia­zol-2-yl)-3-(prop-2-yn­yl)hex-5-yn-2-one

The title compound, C16H13NOS, was prepared by alkyl­ation of 1-(benzothia­zol-2-yl)propan-2-one with propargyl bromide. The asymmetric unit contains two mol­ecules that are crystallographically independent but linked to each other by non-classical C—H⋯O hydrogen bonds, building up a dimeric substructure. The benzothia­zole rings are essentially planar with maximum deviations of 0.005 (1) and 0.007 (2) Å for the N atoms. Although the two mol­ecules have similar bond distances and angles, they slightly differ in the orientation of the benzothia­zole ring with respect to the two propargyl groups and the acetonyl unit . In the crystal, inter­molecular C—H⋯O inter­actions link the dimeric subunits into a two-dimensional array in the bc plane

A simple method to assess the oxidative susceptibility of low density lipoproteins

BACKGROUND: Oxidative modification of low density lipoproteins (LDL) is recognized as one of the major processes involved in atherogenesis. The in vitro standardized measurement of LDL oxidative susceptibility could thus be of clinical significance. The aim of the present study was to establish a method which would allow the evaluation of oxidative susceptibility of LDL in the general clinical laboratory. RESULTS: LDL was isolated from human plasma by selective precipitation with amphipathic polymers. The ability of LDL to form peroxides was assessed by measuring thiobarbituric acid reactive substances (TBARS) after incubation with Cu(2+) and H(2)O(2). Reaction kinetics showed a three-phase pattern (latency, propagation and decomposition phases) which allowed us to select 150 min as the time point to stop the incubation by cooling and EDTA addition. The mixture Cu(2+)/H(2)O(2) yielded more lipoperoxides than each one on its own at the same time end-point. Induced peroxidation was measured in normal subjects and in type 2 diabetic patients. In the control group, results were 21.7 ± 1.5 nmol MDA/mg LDL protein, while in the diabetic group results were significantly increased (39.0 ± 3.0 nmol MDA/mg LDL protein; p < 0.001). CONCLUSION: a simple and useful method is presented for the routine determination of LDL susceptibility to peroxidation in a clinical laboratory

Laser à état solide bi-fréquence sans bruit d’antiphase

National audienceUne réduction de plus de 20 dB du bruit d'antiphase a été obtenue dans un laser bi-fréquence mono-axe sans aucun asservissement d'intensité. Ce résultat repose sur l'utilisation d'un cristal de Nd :YAG taillé selon le plan cristallographique (001) et l'alignement des deux états de polarisation du laser avec deux des axes cristallographiques du Crystal

Potential energy threshold for nano-hillock formation by impact of slow highly charged ions on a CaF2_2(111) surface

We investigate the formation of nano-sized hillocks on the (111) surface of CaF$_2$ single crystals by impact of slow highly charged ions. Atomic force microscopy reveals a surprisingly sharp and well-defined threshold of potential energy carried into the collision of about 14 keV for hillock formation. Estimates of the energy density deposited suggest that the threshold is linked to a solid-liquid phase transition (``melting'') on the nanoscale. With increasing potential energy, both the basal diameter and the height of the hillocks increase. The present results reveal a remarkable similarity between the present predominantly potential-energy driven process and track formation by the thermal spike of swift ($\sim$ GeV) heavy ions.Comment: 10 pages, 2 figure